晶片上的人體細胞

觀賞影片網址：
http://www.ted.com/talks/geraldine_hamilton_body_parts_on_a_chip.html

內容翻譯整理：張家珮 

漢米頓博士在此向大家報告他們的最新研究成果：
人體細胞晶片

以往的實驗，通常有兩種方法：

[細胞培養]
實際人體細胞，但只能模擬有限生理環境

[動物實驗]
具生理環境，但動物非人，許多實驗結論最後仍不適用於人類。

於是，移植入各種人類細胞，與配合實際生理環境創造出的
模擬人體細胞晶片，就此誕生！




請觀賞漢米頓博士精采的演說：

Published on Jul 11, 2013

The development of new medicine is problematic because laboratories cannot replicate the human body's environment, making it difficult to determine how patients will respond to treatment. At TEDxBoston, Geraldine Hamilton demonstrates how scientists can implant living human cells into microchips that mimic the body's conditions. These "organs-on-a-chip" can be used to study drug toxicity, identify potential new therapies, and could lead to safer clinical trials.

新醫學的發展通常困難重重，因為實驗技術無法複製人體環境，以致難以界定患者對實際治療的反應。TEDxBoston的杰拉爾丁·漢密爾頓，展示了科學家如何將人體活細胞植入模仿人體環境的晶片之中。這些「器官晶片」可以用來研究藥物毒性，識別潛力新療法，並可使臨床試驗更加安全。

A cross-disciplinary team of researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University are mimicking life-threatening conditions in microchips that are lined by living human cells. These 'organs-on-a-chip" can be used to study drug toxicity, identify potential new therapies, and open up a whole new way to think about clinical trials.

哈佛大學威斯研究機構，生物啟發工程科技團隊的跨學科研究人員，在植入人類活細胞的晶片中模擬危及生命之狀況。這些「器官晶片」可以用來研究藥物毒性，識別潛在的新療法，開創了全新的臨床試驗思考模式。

Geraldine Hamilton: Bio researcher 

杰拉爾丁·漢密爾頓：生物技術研究者

Geraldine Hamilton builds organs and body parts on a chip -- to test new, custom cures.

杰拉爾丁·漢密爾頓將器官及身體部位植入晶片 - 以測試新型特製的治療方法。

Why you should listen to her

 為什麼要聽她說話:

Geraldine Hamilton’s career spans from academic research to biotech start-ups to pharma. Her research focus has been on the development and application of human-relevant in-vitro models for drug discovery. She was one of the founding scientists, VP of Scientific Operations and Director of Cell Products, in a start-up biotech company (CellzDirect), that successfully translated and commercialized technology from academic research to supply the pharmaceutical industry with hepatic cell products and services for safety assessment and drug-metabolism studies.

杰拉爾丁·漢密爾頓的職業生涯，跨足學術研究，創新生物技術以及醫藥產業。她的研究重點一直是發展與應用與人類相關的體外模型，以利藥物開發。她是一個初創生物技術公司（CellzDirect）的創始科學家之一，以及科學作業細胞產品之副總裁。此公司成功移植及商業化學術研究之技術，提供肝細胞產品及服務給醫藥產業，用於安全評估和藥物代謝研究。

Hamilton received her Ph.D. in cell biology/toxicology from the University of Hertfordshire (England) in conjunction with GlaxoSmithkline, followed by a post-doctoral research fellowship at the University of North Carolina. Her current research interests and prior experience include: organs on-a-chip, toxicology and drug metabolism, liver cell biology, mechanisms regulating gene expression and differentiation, regulation of nuclear receptors and transcriptional activation in hepatocytes by xenobiotics, human cell isolation and cryopreservation techniques.

漢密爾頓獲得了英國赫特福德大學與葛蘭素史克公司配合之細胞生物學/毒理學博士學位，隨後在北卡羅來納大學做博士後研究。她目前的研究興趣和以往的經驗包括：器官晶片，毒理學和藥物代謝，肝細胞生物學，基因表達調控分化，外源性化學物質對細胞核受體和轉錄活化肝細胞的調控，人體細胞分離和冷凍保存技術。

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